Spatial orientation and dynamics of the U1A proteins in the U1A-UTR complex.

@article{Clert2000SpatialOA,
  title={Spatial orientation and dynamics of the U1A proteins in the U1A-UTR complex.},
  author={Caroline Clert{\'e} and Kathleen B Hall},
  journal={Biochemistry},
  year={2000},
  volume={39 24},
  pages={7320-9}
}
The human U1A protein contains three distinct domains: the N-terminal RBD1 (amino acids 1-101), the C-terminal RBD2 (amino acids 195-282), and the linker region (amino acids 102-194). The RBD1 domains of two U1A proteins bind specifically to two internal loops in the 3' untranslated region (3' UTR) of its own pre-mRNA. Tryptophan fluorescence and… CONTINUE READING