Spatial organization of transmembrane receptor signalling.

@article{Bethani2010SpatialOO,
  title={Spatial organization of transmembrane receptor signalling.},
  author={Ioanna Bethani and Sigrid S. Sk{\aa}nland and Ivan Dikic and Amparo Acker-Palmer},
  journal={The EMBO journal},
  year={2010},
  volume={29 16},
  pages={
          2677-88
        }
}
The spatial organization of transmembrane receptors is a critical step in signal transduction and receptor trafficking in cells. Transmembrane receptors engage in lateral homotypic and heterotypic cis-interactions as well as intercellular trans-interactions that result in the formation of signalling foci for the initiation of different signalling networks. Several aspects of ligand-induced receptor clustering and association with signalling proteins are also influenced by the lipid composition… CONTINUE READING
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