Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster

  title={Spatial organization of chromosomes in the salivary gland nuclei of Drosophila melanogaster},
  author={Mark Hochstrasser and David Mathog and Yosef Gruenbaum and Harald Saumweber and John Sedat},
  journal={The Journal of Cell Biology},
  pages={112 - 123}
Using a computer-based system for model building and analysis, three-dimensional models of 24 Drosophila melanogaster salivary gland nuclei have been constructed from optically or physically sectioned glands, allowing several generalizations about chromosome folding and packaging in these nuclei. First and most surprising, the prominent coiling of the chromosomes is strongly chiral, with right-handed gyres predominating. Second, high frequency appositions between certain loci and the nuclear… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 108 extracted citations

MukBEF, a chromosomal organizer.

Journal of molecular microbiology and biotechnology • 2014
View 1 Excerpt
Highly Influenced

Large-scale Chromosomal Movements During Interphase Progression in Drosophila

The Journal of cell biology • 1998
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 38 references

Nucleotypic basis of the spatial ordering of chromosomes in eukaryotes and the implications of the order for genome evolution and phenotypic variation

M. D. Bennett
In Genome Evolution • 1983

Similar Papers

Loading similar papers…