Spatial organization and coordination of slow waves in the mouse anorectum.

@article{Hall2014SpatialOA,
  title={Spatial organization and coordination of slow waves in the mouse anorectum.},
  author={Kerri A Hall and Sean M Ward and Caroline A Cobine and Kathleen D. Keef},
  journal={The Journal of physiology},
  year={2014},
  volume={592 17},
  pages={3813-29}
}
The internal anal sphincter (IAS) develops tone and is important for maintaining a high anal pressure while tone in the rectum is less. The mechanisms responsible for tone generation in the IAS are still uncertain. The present study addressed this question by comparing the electrical properties and morphology of the mouse IAS and distal rectum. The amplitude of tone and the frequency of phasic contractions was greater in the IAS than in rectum while membrane potential (Em) was less negative in… CONTINUE READING