Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

@article{Burguire2005SpatialNI,
  title={Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?},
  author={Eric Burgui{\`e}re and Angelo Arleo and M. R. Hojjati and Ype Elgersma and Chris I. De Zeeuw and Alain Berthoz and Laure Rondi-Reig},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={1292-1294}
}
L7-PKCI transgenic mice, which lack parallel fiber–Purkinje cell long-term depression (LTD), were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and… CONTINUE READING
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