Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?

@article{ValladolidAcebes2013SpatialMI,
  title={Spatial memory impairment and changes in hippocampal morphology are triggered by high-fat diets in adolescent mice. Is there a role of leptin?},
  author={Ismael Valladolid-Acebes and Alberto Fole and Miriam S Martin and Lidia C Morales and Mar{\'i}a Victoria Moreno Cano and Mariano Ruiz-Gayo and Nuria del Olmo},
  journal={Neurobiology of learning and memory},
  year={2013},
  volume={106},
  pages={18-25}
}
Recent evidence has established that consumption of high-fat diets (HFD) is associated with deficits in hippocampus-dependent memory. Adolescence is an important period for shaping learning and memory acquisition that could be particularly sensitive to the detrimental effects of HFD. In the current study we have administered this kind of diets to both adolescent (5-week old) and young adult (8-week old) male C57BL mice during 8 weeks and we have evaluated its effect on (i) spatial memory… CONTINUE READING

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