Spatial mapping of nitric oxide generation in the ischemic heart using electron paramagnetic resonance imaging.

@article{Kuppusamy1996SpatialMO,
  title={Spatial mapping of nitric oxide generation in the ischemic heart using electron paramagnetic resonance imaging.},
  author={Periannan Kuppusamy and Ping Wang and Alexandre Samouilov and Jay L. Zweier},
  journal={Magnetic resonance in medicine},
  year={1996},
  volume={36 2},
  pages={212-8}
}
Recently, it has been shown that rat hearts subjected to global ischemia generate nitric oxide (NO) and that a significant portion of it is generated by the reduction of nitrite under the acidic and reducing conditions that occur during myocardial ischemia [Zweier, Wang, Samouilov, Kuppusamy, Nature Med. 1, 804-809 (1995)]. In the present study it is further attempted to map the spatial distributions of the NO generation in the ischemic myocardium using L-band electron paramagnetic resonance… CONTINUE READING