Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat

  title={Spatial mapping: definitive disruption by hippocampal or medial frontal cortical damage in the rat},
  author={Robert J Sutherland and Bryan E Kolb and Ian Q. Whishaw},
  journal={Neuroscience Letters},
Disruption of spatial but not object-recognition memory by neurotoxic lesions of the dorsal hippocampus in rats.
The finding that partial hippocampal lesions disrupt spatial memory while leaving object-recognition memory intact indicates a specialized role for the hippocampus in mnemonic processes.
Hippocampal lesions and path integration
The Flexible Use of Multiple Cue Relationships in Spatial Navigation: A Comparison of Water Maze Performance Following Hippocampal, Medial Septal, Prefrontal Cortex, or Posterior Parietal Cortex Lesions
The results suggest that the sham-operated control, posterior parietal cortex-lesioned rats, and medial septal area-LESioned rats were able to navigate effectively under changing task conditions and the navigational performances of the prefrontal cortex- and hippocampal formation-lesion rats were impaired when task demands changed.
The role of medial prefrontal cortex in context-specific inhibition during reversal learning of a visual discrimination
These and other results from a transfer test suggest that the medial prefrontal cortex participates in the behavioral effects of a context-specific inhibitory association acquired during visual discrimination learning.
A comparison of the contributions of the frontal and parietal association cortex to spatial localization in rats.
The results suggest that the frontal andParietal cortex of rats play different roles in the control of spatial orientation but do not support the view that egocentric and allocentric spatial orientation are related to frontal and parietal mechanisms, respectively.


Prefrontal system in the rat visualized by means of labeled deoxyglucose—further evidence for functional heterogeneity of the neostriatum
An epileptic focus was formed in the anteromedial part of the prefrontal cortex in rats by means of intracortical injection of penicillin, and radioactively labeled deoxyglucose was immediately
The function of septo-hippocampal connections in spatially organized behaviour.
  • D. Olton
  • Biology, Psychology
    Ciba Foundation symposium
  • 1977
Evidence suggests an important role of the septo-hippocampal system in spatial behaviour, and in the maintenance of spatial memories, is indicated and disruptive stimulation of the hippocampus while rats are performing a spatial memory task produces retrograde amnesia but not proactive interference.