Spatial light interference microscopy: principle and applications to biomedicine.

  title={Spatial light interference microscopy: principle and applications to biomedicine.},
  author={Xi Chen and Mikhail Eugene Kandel and Gabriel Popescu},
  journal={Advances in optics and photonics},
  volume={13 2},
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-shifting interferometer, built onto a phase-contrast microscope, with white-light illumination. As one of the most sensitive quantitative phase imaging (QPI) methods, SLIM allows for speckle-free phase reconstruction with sub-nanometer path-length stability. We first review image formation in QPI, scattering, and full-field methods. Then, we outline SLIM imaging from theory and instrumentation to… 

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