Spatial learning deficits without hippocampal neuronal loss in a model of early-onset epilepsy.

@article{Lee2001SpatialLD,
  title={Spatial learning deficits without hippocampal neuronal loss in a model of early-onset epilepsy.},
  author={Chong Lek Lee and Jules Hannay and R Hrachovy and Samiya Rashid and Barbara C Antalffy and John W. Swann},
  journal={Neuroscience},
  year={2001},
  volume={107 1},
  pages={71-84}
}
Studies were undertaken to examine the effects recurrent early-life seizures have on the ability of rats to acquire spatial memories in adulthood. A minute quantity of tetanus toxin was injected unilaterally into the hippocampus on postnatal day 10. Within 48 h, rats developed recurrent seizures that persisted for 1 week. Between postnatal days 57 and 61, rats were trained in a Morris water maze. Toxin-injected rats were markedly deficient in learning this task. While these rats showed gradual… CONTINUE READING