Spatial learning deficits in mice lacking A-type K(+) channel subunits.

  title={Spatial learning deficits in mice lacking A-type K(+) channel subunits.},
  author={Amber D. Lockridge and Li-Lian Yuan},
  volume={21 11},
Kv4.2-mediated A-type K(+) channels in dendrites act to dampen back-propagating action potentials, constrain coincidence detection, and modify synaptic properties. Because of naturally high concentrations in the hippocampus, genetic deletion of this protein results in enhanced CA1 dendritic excitability and a broader signal integration time window with potential implications for spatial learning. In this investigation, we tested Kv4.2 knockout mice in the Morris water maze to assess their… CONTINUE READING

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What’s Wrong With My Mouse?: Behavioral Phenotyping of Transgenic and Knockout Mice

  • Crawley JN.
  • New York: Wiley-Liss.
  • 2000

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