Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization.

@article{Williamson2014SpatialGO,
  title={Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization.},
  author={Iain D M Williamson and Soizik Berlivet and Ragnhild Eskeland and Shelagh Boyle and Robert S. Illingworth and Denis Paquette and Josee Dostie and Wendy A. Bickmore},
  journal={Genes & development},
  year={2014},
  volume={28 24},
  pages={2778-91}
}
Although important for gene regulation, most studies of genome organization use either fluorescence in situ hybridization (FISH) or chromosome conformation capture (3C) methods. FISH directly visualizes the spatial relationship of sequences but is usually applied to a few loci at a time. The frequency at which sequences are ligated together by formaldehyde cross-linking can be measured genome-wide by 3C methods, with higher frequencies thought to reflect shorter distances. FISH and 3C should… CONTINUE READING
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