Spatial distribution of VEGF isoforms and chemotactic signals in the vicinity of a tumor.

Abstract

We propose a mathematical model that describes the formation of gradients of different isoforms of vascular endothelial growth factor (VEGF). VEGF is crucial in the process of tumor-induced angiogenesis, and recent experiments strongly suggest that the molecule is most potent when bound to the extracellular matrix (ECM). Using a system of reaction-diffusion… (More)
DOI: 10.1016/j.jtbi.2008.02.009

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@article{Small2008SpatialDO, title={Spatial distribution of VEGF isoforms and chemotactic signals in the vicinity of a tumor.}, author={Alexander R. Small and Adrian Neagu and Franck Amyot and Dan L. Sackett and Victor Chernomordik and Amir Gandjbakhche}, journal={Journal of theoretical biology}, year={2008}, volume={252 4}, pages={593-607} }