Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma.

  title={Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma.},
  author={Giovanni Francesco Castino and Nina Cortese and Giovanni Capretti and Simone Serio and Giuseppe Di Caro and Rossana Mineri and Elena Magrini and Fabio Grizzi and Paola Cappello and Francesco Novelli and Paola Spaggiari and Massimo G Roncalli and Cristina Ridolfi and Francesca Gavazzi and Alessandro Zerbi and Paola Allavena and Federica Marchesi},
  volume={5 4},
B-cell responses are emerging as critical regulators of cancer progression. In this study, we investigated the role of B lymphocytes in the microenvironment of human pancreatic ductal adenocarcinoma (PDAC), in a retrospective consecutive series of 104 PDAC patients and in PDAC preclinical models. Immunohistochemical analysis revealed that B cells occupy two histologically distinct compartments in human PDAC, either scatteringly infiltrating (CD20-TILs), or organized in tertiary lymphoid tissue… CONTINUE READING
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