Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: effects of chronic treatment with acetyl-L-carnitine.

@article{Prickaerts1995SpatialDL,
  title={Spatial discrimination learning and choline acetyltransferase activity in streptozotocin-treated rats: effects of chronic treatment with acetyl-L-carnitine.},
  author={Jos Prickaerts and Arjan Blokland and Wiel H H Honig and Fan-jie Meng and Jelle Jolles},
  journal={Brain research},
  year={1995},
  volume={674 1},
  pages={142-6}
}
Treatment of rats with i.c.v. injected streptozotocin (STREP) may provide a relevant model of neurodegeneration that is induced by a decrease in the central metabolism of glucose. Acetyl-L-carnitine (ALCAR) enhances the utilization of alternative energy sources and by such a mechanism of action ALCAR could antagonize the effects of STREP treatment. In this study the effects of chronic treatment with ALCAR were evaluated on spatial discrimination learning in the Morris task and choline… CONTINUE READING