Spatial covariation of mutation and nonsynonymous substitution rates in vertebrate mitochondrial genomes.

Abstract

Mitochondrial genomes encode fundamental subunits of the basic energy producing machinery of eukaryotic cells that are under strong functional constraint. Paradoxically, these genes evolve rapidly in general, and there is substantial variation in evolutionary rates among genes within genomes. In order to investigate spatial variation in selection intensity… (More)

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