Spatial control of gene expression within a scaffold by localized inducer release.

@article{Baraniak2011SpatialCO,
  title={Spatial control of gene expression within a scaffold by localized inducer release.},
  author={Priya R. Baraniak and Devin M. Nelson and Cory E. Leeson and Anand K Katakam and Jennifer L Friz and Dean E. Cress and Yi Hong and Jianjun Guan and William R Wagner},
  journal={Biomaterials},
  year={2011},
  volume={32 11},
  pages={3062-71}
}
Gene expression can be controlled in genetically modified cells by employing an inducer/promoter system where presence of the inducer molecule regulates the timing and level of gene expression. By applying the principles of controlled release, it should be possible to control gene expression on a biomaterial surface by the presence or absence of inducer release from the underlying material matrix, thus avoiding alternative techniques that rely upon uptake of relatively labile DNA from material… CONTINUE READING
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