Spatial control of adult stem cell fate using nanotopographic cues.

@article{Ahn2014SpatialCO,
  title={Spatial control of adult stem cell fate using nanotopographic cues.},
  author={Eun Hyun Ahn and Younghoon Kim and Kshitiz and Steven S. An and Junaid Afzal and Suengwon Lee and Moonkyu Kwak and K. C. Suh and Deok-Ho Kim and Andre Levchenko},
  journal={Biomaterials},
  year={2014},
  volume={35 8},
  pages={2401-2410}
}
Adult stem cells hold great promise as a source of diverse terminally differentiated cell types for tissue engineering applications. However, due to the complexity of chemical and mechanical cues specifying differentiation outcomes, development of arbitrarily complex geometric and structural arrangements of cells, adopting multiple fates from the same initial stem cell population, has been difficult. Here, we show that the topography of the cell adhesion substratum can be an instructive cue to… CONTINUE READING
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