Spatial compartmentalization at the nuclear periphery characterized by genome-wide mapping

@inproceedings{Wu2012SpatialCA,
  title={Spatial compartmentalization at the nuclear periphery characterized by genome-wide mapping},
  author={Feinan Wu and Jie Yao},
  booktitle={Epigenetics & Chromatin},
  year={2012}
}
How gene positioning to the nuclear periphery regulates transcription remains largely unclear. By cell imaging, we have previously observed the differential compartmentalization of transcription factors and histone modifications at the nuclear periphery in mouse C2C12 myoblasts. Here, we aim to identify DNA sequences associated with the nuclear lamina (NL) and examine this compartmentalization at the genome-wide level. We have integrated high throughput DNA sequencing into the DNA adenine… CONTINUE READING
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