Spatial colocalization and functional link of purinosomes with mitochondria

  title={Spatial colocalization and functional link of purinosomes with mitochondria},
  author={Jarrod B French and Sara A. Jones and Huayun Deng and Anthony M Pedley and Doory Kim and Chung Yu Chan and Haibei Hu and Raymond J. Pugh and Hong Zhao and Youxin Zhang and Tony Jun Huang and Ye Fang and Xiaowei Zhuang and Stephen J Benkovic},
Purine biosynthetic enzymes organize into dynamic cellular bodies called purinosomes. Little is known about the spatiotemporal control of these structures. Using super-resolution microscopy, we demonstrated that purinosomes colocalized with mitochondria, and these results were supported by isolation of purinosome enzymes with mitochondria. Moreover, the number of purinosome-containing cells responded to dysregulation of mitochondrial function and metabolism. To explore the role of intracellular… CONTINUE READING
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  • C. Jose, N. Bellance, R. Rossignol
  • Biophys. Acta
  • 1807
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