Spatial cognition and the human navigation network in AD and MCI

@article{Deipolyi2007SpatialCA,
  title={Spatial cognition and the human navigation network in AD and MCI},
  author={Amy R. Deipolyi and Kelsey Rankin and Lennart Mucke and Bruce L. Miller and M. L. Gorno-Tempini},
  journal={Neurology},
  year={2007},
  volume={69},
  pages={986 - 997}
}
Background: The mechanisms underlying navigation impairments in Alzheimer disease (AD) are unknown. We characterized navigation in AD and mild cognitive impairment (MCI) to test the hypothesis that navigation disability reflects selective impairments in spatial cognition and relates to atrophy of specific brain regions. Methods: We compared 13 mild AD and 21 MCI patients with 24 controls on a route-learning task that engaged various spatial processes. Using structural MRI and optimized voxel… Expand

Paper Mentions

Observational Clinical Trial
Despite the high prevalence of Alzheimer's disease (AD), its underlying mechanisms remain poorly understood. An emerging body of evidence supports disorientation as an early marker… Expand
ConditionsAlzheimer Disease, Mild Cognitive Impairment
InterventionDevice
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Spatial Navigation Impairment Is Associated with Alterations in Subcortical Intrinsic Activity in Mild Cognitive Impairment: A Resting-State fMRI Study
TLDR
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TLDR
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5 Spatial Navigation Impairment in Healthy Aging and Alzheimer ’ s Disease
The prevailing number of studies dealing with spatial navigation in animals and also in human have been connecting it to the function of the medial-temporal lobe (MTL), hypothesized to serve as theExpand
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