Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: An immunohistochemical colocalization study

@article{Myhnen2008SpatialAO,
  title={Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: An immunohistochemical colocalization study},
  author={Timo T My{\"o}h{\"a}nen and Jarkko I. Ven{\"a}l{\"a}inen and J. A. Garcia-horsman and Pekka Topias Maennistoe},
  journal={Neuroscience},
  year={2008},
  volume={153},
  pages={1177-1189}
}
Prolyl oligopeptidase (POP) is a serine endopeptidase which hydrolyzes proline-containing peptides shorter than 30 amino acids. It has been suggested that POP is associated with cognitive functions, possibly via the cleavage of neuropeptides such as substance P (SP). Recently, several studies have also linked POP to the inositol 1,4,5-triphosphate (IP(3)) signaling. However, the neuroanatomical interactions between these substances are not known. We used double-labeled immunofluorescence to… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 76 REFERENCES

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats

AJ alkanen, KA Puttonen, +6 authors PT Männistö
  • Basic Clin Pharmacol Toxicol
  • 2007

On the role of prolyl oligopeptidase in health and disease

JA arcia-Horsman, PT Männistö, JI Venäläinen
  • Neuropeptides
  • 2007
VIEW 1 EXCERPT