Spatial association of HIV-1tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells

@article{Marasco1994SpatialAO,
  title={Spatial association of HIV-1tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells},
  author={Wayne A. Marasco and Anne Marie Szilvay and Karl- Henning Kalland and D. G. Helland and Hernan M. Reyes and Robert P. Walter},
  journal={Archives of Virology},
  year={1994},
  volume={139},
  pages={133-154}
}
The human immunodeficiency virus (HIV-1) encodes a transactivator protein, the product of the tat gene (tat), which is essential for virus replication. In this study, immunogold electron microscopy was used in a stably transfected Jurkat T-cell line that constitutively expresses HIV-1tat protein to determine the subcellular and intranuclear distribution oftat protein. Two nucleocytoplasmic shuttle proteins C23/nucleolin and B23 and a third nucleolar antigen that was detected by monoclonal… CONTINUE READING

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