Spatial and temporal variation of passer Per2 gene expression in two distinct cell groups of the suprachiasmatic hypothalamus in the house sparrow (Passer domesticus)

@article{Abraham2002SpatialAT,
  title={Spatial and temporal variation of passer Per2 gene expression in two distinct cell groups of the suprachiasmatic hypothalamus in the house sparrow (Passer domesticus)},
  author={Ute Abraham and Urs Albrecht and Eberhard Gwinner and Roland Brandst{\"a}tter},
  journal={European Journal of Neuroscience},
  year={2002},
  volume={16}
}
In mammals, the major pacemaker controlling circadian rhythmicity is located in the hypothalamic suprachiasmatic nuclei. Although there is evidence for the presence of a hypothalamic circadian oscillator in birds from lesioning studies, neuroanatomical, neurochemical and functional investigations have failed to identify its exact location. Two cell groups in the avian hypothalamus have been shown to bear characteristics of the mammalian suprachiasmatic nucleus: the suprachiasmatic nucleus and… 
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  • R. Brandstaetter
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 2004
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Takahashi and Menaker extended this view by providing evidence for the multioscillatory nature of the house sparrow circadian system, demonstrating the presence of hypothalamic components and the necessity of coupling of oscillators to maintain rhythmicity.
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The results point to the existence of differences in the organization of avian and mammalian circadian clock mechanisms, with mRNA levels varying considerably between the various genes.
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