Spatial and temporal imaging of gas phase protein and DNA produced by matrix-assisted laser desorption.

Abstract

The sensitivity of a transient imaging technique based on laser-excited fluorescence is shown to be within the levels required for studying matrix-assisted laser-desorption (MALD) of large biomolecules. Results show that film morphology, particularly film thickness, has a major influence on plume dynamics. Fluorescent labeling of protein and of DNA is used… (More)

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