Spatial and temporal expression of p57KIP2 during murine lens development

  title={Spatial and temporal expression of p57KIP2 during murine lens development},
  author={Frank J. Lovicu and John W. McAvoy},
  journal={Mechanisms of Development},
The expression patterns of p57(KIP2), an important cyclin-dependent kinase inhibitor in the lens, is investigated. This study shows that the expression of p57 mRNA throughout lens morphogenesis and growth correlates with lens cell withdrawal from the cell cycle (shown by changing patterns of BrdU incorporation) and the onset of lens fibre differentiation (shown by beta-crystallin expression). p57 expression at the early stages of fibre differentiation make it a useful marker for the initiation… CONTINUE READING
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