Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury.

@article{Lepore2011SpatialAT,
  title={Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury.},
  author={Angelo C. Lepore and John G O'Donnell and Joseph F Bonner and Courtney Paul and Mark E Miller and Britta Rauck and Robert A Kushner and Jeffrey D Rothstein and Itzhak Fischer and Nicholas J. Maragakis},
  journal={Journal of neuroscience research},
  year={2011},
  volume={89 7},
  pages={1001-17}
}
After traumatic spinal cord injury (SCI), there is an opportunity for preserving function by attenuating secondary cell loss. Astrocytes play crucial roles in the adult CNS and are responsible for the vast majority of glutamate buffering, potentially preventing excitotoxic loss of neurons and oligodendrocytes. We examined spatial and temporal changes in gene expression of the major astrocyte glutamate transporter GLT1 following moderate thoracic contusion SCI using transgenic BAC-GLT1-eGFP… CONTINUE READING

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