Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

@article{Burgdorf2008SpatialAM,
  title={Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation},
  author={Sven Burgdorf and Christian Sch{\"o}lz and Andreas Kautz and Robert Tamp{\'e} and Christian Kurts},
  journal={Nature Immunology},
  year={2008},
  volume={9},
  pages={558-566}
}
Antiviral or antitumor immunity requires activation of cytotoxic CD8+ T cells by dendritic cells, which present viral or tumor antigens on major histocompatibility complex (MHC) class I molecules. The intracellular mechanisms facilitating MHC class I–restricted presentation of extracellular antigens ('cross-presentation') are unclear. Here we demonstrate that cross-presentation of soluble antigen occurred in an early endosomal compartment distinct from the endoplasmic reticulum where endogenous… CONTINUE READING
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Cross - priming

  • M. J. Bevan
  • Nat . Immunol .
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