Spatial and Temporal Analysis of Alphavirus Replication and Assembly in Mammalian and Mosquito Cells

Abstract

Sindbis virus (SINV [genus Alphavirus, family Togaviridae]) is an enveloped, mosquito-borne virus. Alphaviruses cause cytolytic infections in mammalian cells while establishing noncytopathic, persistent infections in mosquito cells. Mosquito vector adaptation of alphaviruses is a major factor in the transmission of epidemic strains of alphaviruses. Though… (More)
DOI: 10.1128/mBio.02294-16

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