Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations

@inproceedings{Philippeos2018SpatialAS,
  title={Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations},
  author={Christina Philippeos and St{\'e}phanie B. Telerman and B{\'e}n{\'e}dicte Oul{\`e}s and Angela Oliveira Pisco and Tanya J. Shaw and Raul Elgueta and Giovanna Lombardi and Ryan R Driskell and Mark George Soldin and Magnus David Lynch and Fiona M Watt},
  booktitle={The Journal of investigative dermatology},
  year={2018}
}
Previous studies have shown that mouse dermis is composed of functionally distinct fibroblast lineages. To explore the extent of fibroblast heterogeneity in human skin, we used a combination of comparative spatial transcriptional profiling of human and mouse dermis and single-cell transcriptional profiling of human dermal fibroblasts. We show that there are at least four distinct fibroblast populations in adult human skin, not all of which are spatially segregated. We define markers permitting… CONTINUE READING
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