Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I

@article{Chmtal2015SpatialRO,
  title={Spatial Regulation of Kinetochore Microtubule Attachments by Destabilization at Spindle Poles in Meiosis I},
  author={Luk{\'a}{\vs} Chm{\'a}tal and Karren Yang and Richard M Schultz and Michael A Lampson},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={1835-1841}
}
To ensure accurate chromosome segregation in cell division, erroneous kinetochore-microtubule (MT) attachments are recognized and destabilized . Improper attachments typically lack tension between kinetochores and are positioned off-center on the spindle. Low tension is a widely accepted mechanism for recognizing errors , but whether chromosome position regulates MT attachments has been difficult to test. We exploited a meiotic system in which kinetochores attached to opposite spindle poles… CONTINUE READING
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a2015 Elsevier L strength provides the cell biological basis for meiotic drive and karyotype evolution in mice

  • L. Chmátal, S. I. Gabriel, +5 authors M. A. Lampson
  • Centromere
  • 2014
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