Spatial Distribution of Bax and Bcl‐2 in Osteocytes After Bone Fatigue: Complementary Roles in Bone Remodeling Regulation?

@article{Verborgt2002SpatialDO,
  title={Spatial Distribution of Bax and Bcl‐2 in Osteocytes After Bone Fatigue: Complementary Roles in Bone Remodeling Regulation?},
  author={O. Verborgt and N. Tatton and R. Majeska and M. Schaffler},
  journal={Journal of Bone and Mineral Research},
  year={2002},
  volume={17}
}
  • O. Verborgt, N. Tatton, +1 author M. Schaffler
  • Published 2002
  • Biology, Medicine
  • Journal of Bone and Mineral Research
  • Osteocyte apoptosis appears to play a key role in the mechanism by which osteoclastic resorption activity targets bone for removal, because osteocyte apoptosis occurs in highly specific association with microdamage and subsequent remodeling after fatigue. However, beyond terminal deoxynucleotidyl transferase (TdT)‐mediated deoxyuridine triphosphate (dUTP)‐biotin nick end labeling (TUNEL) assay, little is known about the mechanisms controlling osteocyte apoptosis in vivo. In the current studies… CONTINUE READING
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