Spatial Control of Biological Ligands on Surfaces Applied to T Cell Activation.

@article{Cai2017SpatialCO,
  title={Spatial Control of Biological Ligands on Surfaces Applied to T Cell Activation.},
  author={Haogang Cai and David Depoil and James B. Muller and Michael P Sheetz and Michael L. Dustin and Shalom J. Wind},
  journal={Methods in molecular biology},
  year={2017},
  volume={1584},
  pages={307-331}
}
In this chapter, we present techniques, based on molecular-scale nanofabrication and selective self-assembly, for the presentation of biomolecules of interest (ligands, receptors, etc.) on a surface with precise spatial control and arbitrary geometry at the single-molecule level. Metallic nanodot arrays are created on glass coverslips and are then used as… CONTINUE READING