Spastin-Interacting Protein NA14/SSNA1 Functions in Cytokinesis and Axon Development

Abstract

Hereditary spastic paraplegias (HSPs) are a genetically diverse group of inherited neurological disorders (SPG1-72) with the cardinal feature of prominent lower-extremity spasticity due to a length-dependent axonopathy of corticospinal motor neurons. The most frequent form of autosomal dominant HSP results from mutations of the SPG4 gene product spastin… (More)
DOI: 10.1371/journal.pone.0112428

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