Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein

@article{Mannan2006SpastinTM,
  title={Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein},
  author={Ashraf U. Mannan and Johann Boehm and Simone M. Sauter and Anne Rauber and Paula Catherine Byrne and Juergen Neesen and Wolfgang Engel},
  journal={Neurogenetics},
  year={2006},
  volume={7},
  pages={93-103}
}
Spastin, an ATPase belonging to the AAA family of proteins is most commonly mutated in autosomal dominant hereditary spastic paraplegias (HSP). Spastin is a multifaceted protein with versatile role in cellular events, principally involved in microtubule dynamics. To gain further insight into the molecular function of spastin, we used the yeast two-hybrid approach to identify novel interacting partners of spastin. Using spastin as bait, we identified reticulon 1 (RTN1) and reticulon 3 (RTN3) as… CONTINUE READING

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