Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum

@article{CavalcanteSilva2013SpasmolyticEO,
  title={Spasmolytic Effect of Caulerpine Involves Blockade of Ca2+ Influx on Guinea Pig Ileum},
  author={L. H. A. Cavalcante-Silva and Ana Carolina de Carvalho Correia and J. Barbosa-Filho and Bagn{\'o}lia Ara{\'u}jo da Silva and B. V. de Oliveira Santos and D. P. de Lira and J{\'e}ssica Celestino Ferreira Sousa and G. E. C. de Miranda and Fabiana de Andrade Cavalcante and M. S. Alexandre-Moreira},
  journal={Marine Drugs},
  year={2013},
  volume={11},
  pages={1553 - 1564}
}
In this work, we investigated the spasmolytic effect of caulerpine, a bisindole alkaloid isolated from marine algae of the Caulerpa genus, on guinea pig ileum. Our findings indicated that caulerpine inhibited phasic contractions induced by carbachol (IC50 = 7.0 ± 1.9 × 10−5 M), histamine (IC50 = 1.3 ± 0.3 × 10−4 M) and serotonin (IC50 = 8.0 ± 1.4 × 10−5 M) in a non-selective manner. Furthermore, caulerpine concentration-dependently inhibited serotonin-induced cumulative contractions (pD′2 = 4… Expand
Assessment of Mechanisms Involved in Antinociception Produced by the Alkaloid Caulerpine
1H NMR Spectroscopy and MVA to Evaluate the Effects of Caulerpin-Based Diet on Diplodus sargus Lipid Profiles
...
1
2
3
...

References

SHOWING 1-10 OF 67 REFERENCES
Calcium antagonists and contractile responses in rat vas deferens and guinea pig ileal smooth muscle.
Spasmolytic actions of the new indole alkaloid Trinervine from Strychnos trinervis root.
Involvement of protein kinase C in muscarinic agonist-induced contractions of guinea pig ileal longitudinal muscle.
Calcium and sodium dependence of the biphasic response of the guinea-pig ileum to agonists.
Identification of 5HT2-receptors on longitudinal muscle of the guinea pig ileum.
Contractile role of M2 and M3 muscarinic receptors in gastrointestinal smooth muscle.
...
1
2
3
4
5
...