Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry.

@article{Tyndale1990SparteineMC,
  title={Sparteine metabolism capacity in human liver: structural variants of human P450IID6 as assessed by immunochemistry.},
  author={Rachel F. Tyndale and Frank J. Gonzalez and James P. Hardwick and Werner Kalow and Tadanobu Inaba},
  journal={Pharmacology & toxicology},
  year={1990},
  volume={67 1},
  pages={14-8}
}
An antibody raised against rat P450dbl was used to examine the heterogeneity of the human enzyme involved in the sparteine/debrisoquine polymorphism. The extent to which the antibody was able to inhibit sparteine metabolism varied in different human livers (10-80%, n = 9) and reflected the amount of sparteine metabolism carried out by the polymorphic P450IID6 in individual liver specimens. The individual sample variation in inhibition by the antibody correlated with the inhibition caused by… CONTINUE READING

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