Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response.

@article{Centore2012SpartanC1orf124AR,
  title={Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response.},
  author={Richard C. Centore and Stephanie A. Yazinski and Alice Ping Ping Tse and L. Q. Zou},
  journal={Molecular cell},
  year={2012},
  volume={46 5},
  pages={
          625-35
        }
}
PCNA is a key component of DNA replication and repair machineries. DNA damage-induced PCNA ubiquitylation serves as a molecular mark to orchestrate postreplication repair. Here, we have identified and characterized Spartan, a protein that specifically recognizes ubiquitylated PCNA and plays an important role in cellular resistance to UV radiation. In vitro, Spartan engages ubiquitylated PCNA via both a PIP box and a UBZ domain. In cells, Spartan is recruited to sites of UV damage in a manner… CONTINUE READING
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Spartan/C1orf124 is important to prevent UV-induced mutagenesis.

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