Sparse-Grid-Based Adaptive Model Predictive Control of HL60 Cellular Differentiation

@article{Noble2012SparseGridBasedAM,
  title={Sparse-Grid-Based Adaptive Model Predictive Control of HL60 Cellular Differentiation},
  author={Sarah L. Noble and Lindsay E. Wendel and Maia M. Donahue and Gregery T. Buzzard and Ann E. Rundell},
  journal={IEEE Transactions on Biomedical Engineering},
  year={2012},
  volume={59},
  pages={456-463}
}
  • Sarah L. Noble, Lindsay E. Wendel, +2 authors Ann E. Rundell
  • Published in
    IEEE Transactions on…
    2012
  • Computer Science, Medicine
  • Quantitative methods such as model-based predictive control are known to facilitate the design of strategies to manipulate biological systems. This study develops a sparse-grid-based adaptive model predictive control (MPC) strategy to direct HL60 cellular differentiation. Sparse-grid sampling and interpolation support a computationally efficient adaptive MPC scheme in which multiple data-consistent regions of the model parameter space are identified and used to calculate a control compromise… CONTINUE READING

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