Sparse, Decorrelated Odor Coding in the Mushroom Body Enhances Learned Odor Discrimination

@inproceedings{Lin2014SparseDO,
  title={Sparse, Decorrelated Odor Coding in the Mushroom Body Enhances Learned Odor Discrimination},
  author={Andrew C. Y. Lin and Alexei M Bygrave and Alix de Calignon and Tzumin Lee and Gero Miesenb{\"o}ck},
  booktitle={Nature Neuroscience},
  year={2014}
}
Sparse coding may be a general strategy of neural systems for augmenting memory capacity. In Drosophila melanogaster, sparse odor coding by the Kenyon cells of the mushroom body is thought to generate a large number of precisely addressable locations for the storage of odor-specific memories. However, it remains untested how sparse coding relates to behavioral performance. Here we demonstrate that sparseness is controlled by a negative feedback circuit between Kenyon cells and the GABAergic… CONTINUE READING
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