Sparing radiation-induced damage to the physis by radioprotectant drugs: laboratory analysis in a rat model.

@article{Tamurian1999SparingRD,
  title={Sparing radiation-induced damage to the physis by radioprotectant drugs: laboratory analysis in a rat model.},
  author={Robert M Tamurian and Timothy A. Damron and Joseph A. Spadaro},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={1999},
  volume={17 2},
  pages={286-92}
}
The radioprotectant compound amifostine (S-2[3-aminopropylamino]-ethylphosphorothioic acid), administered prior to radiotherapy, has been demonstrated to provide differential protection of normal cells from the damaging effects of ionizing radiation. The aim of this pilot was to determine if amifostine could preserve the integrity of, or minimize the damage to, the physis during exposure to radiation in an animal model. Thirty weanling Sprague-Dawley rats were randomized into five groups of six… CONTINUE READING