Sparing of neuronal function postseizure with gene therapy.

  title={Sparing of neuronal function postseizure with gene therapy.},
  author={Jami McLaughlin and Benno Roozendaal and Theodore C Dumas and Anupma Gupta and Olusola Ajilore and Jenny Hsieh and Daniel Ho and Marion Lawrence and James McGaugh and Robert Morris Sapolsky},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 23},
Numerous studies have demonstrated that gene therapy interventions can protect neurons from death after neurological insults. In nearly all such studies, however, "protection" consists of reduced neurotoxicity, with no demonstrated preservation of neuronal function. We used a herpes simplex virus-1 system to overexpress either the Glut-1 glucose transporter… CONTINUE READING