Spargel/dPGC-1 is a new downstream effector in the insulin-TOR signaling pathway in Drosophila.

@article{Mukherjee2013SpargeldPGC1IA,
  title={Spargel/dPGC-1 is a new downstream effector in the insulin-TOR signaling pathway in Drosophila.},
  author={Subhas Mukherjee and Atanu Duttaroy},
  journal={Genetics},
  year={2013},
  volume={195 2},
  pages={433-41}
}
Insulin and target of rapamycin (TOR) signaling pathways converge to maintain growth so a proportionate body form is attained. Insufficiency in either insulin or TOR results in developmental growth defects due to low ATP level. Spargel is the Drosophila homolog of PGC-1, which is an omnipotent transcriptional coactivator in mammals. Like its mammalian counterpart, Spargel/dPGC-1 is recognized for its role in energy metabolism through mitochondrial biogenesis. An earlier study demonstrated that… CONTINUE READING

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