Spare respiratory capacity, oxidative stress and excitotoxicity.

@article{Nicholls2009SpareRC,
  title={Spare respiratory capacity, oxidative stress and excitotoxicity.},
  author={David G. Nicholls},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 6},
  pages={1385-8}
}
Chronic exposure to glutamate (glutamate excitotoxicity) exacerbates neuronal damage in the aftermath of stroke and is implicated in a variety of neurodegenerative disorders. Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures. 

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