Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists.

@article{Watts1995SpareRA,
  title={Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists.},
  author={Val J. Watts and Cindy Lawler and Andrea J. Gonzales and Qun Yong Zhou and Olivier Civelli and David E. Nichols and Richard B. Mailman},
  journal={Synapse},
  year={1995},
  volume={21 2},
  pages={177-87}
}
The intrinsic activities of selected dopamine D1 receptor agonists were compared in three distinct molecular expression systems, C-6, Ltk, and GH4 cells transfected with primate D1A receptors. The influence of the cell expression system on intrinsic activity varied markedly among agonists. Dihydrexidine (DHX), a potent full agonist with dramatic antiparkinsonian actions, displayed intrinsic activity similar to dopamine in all three cell lines. In contrast, SKF82958 and SKF38393 (full and… CONTINUE READING
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