Spanning binding sites on allosteric proteins with polymer-linked ligand dimers

@article{Kramer1998SpanningBS,
  title={Spanning binding sites on allosteric proteins with polymer-linked ligand dimers},
  author={Richard H. Kramer and Jeffrey W. Karpen},
  journal={Nature},
  year={1998},
  volume={395},
  pages={710-713}
}
One approach to drug design involves determination of the structure of binding sites on target proteins to provide templates for ligand construction. Alternatively, random combinations of chemical groups can be used to generate diverse molecules for screening in the search for effective compounds. Here we report a strategy for developing potent ligands for proteins with multiple binding sites, which combines elements of both approaches: ‘polymer-linked ligand dimers’, in which two ligands are… CONTINUE READING
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