Spanish influenza redux: revisiting the mother of all pandemics

  title={Spanish influenza redux: revisiting the mother of all pandemics},
  author={Mark Honigsbaum},
  journal={The Lancet},
The matrix segment of the “Spanish flu” virus originated from intragenic recombination between avian and human influenza A viruses
The M segment of the Spanish flu virus is a recombinant chimera originating from avian influenza virus and human influenza virus, showing that the recombination might play an important role in inducing high pathogenicity of the virus.
The Second- vs First-wave COVID-19: More of the Same or a Lot Worse? A Comparison of Mortality between the Two Waves in Patients Admitted to Intensive Care Units in Nine Hospitals in Western Maharashtra
  • K. Zirpe, S. Dixit, A. Joshi
  • Medicine
    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
  • 2021
On multivariable regression, male gender, ICU admission during the second wave, increasing HRCT score, and need for intubation and mechanical ventilation were significant predictors of ICU mortality.
Challenges of students and residents of human medicine in the first four months of the fight against the Covid-19 pandemic – Implications for future waves and scenarios
A summary of the literature that addresses the challenges of students and residents of human medicine in the first 4 months of the fight against the Covid-19 pandemic to identify gaps and find implications for improvement within the current situation and for potential future scenarios.
Using Experience in Previous Epidemics for Effective Containing SARS-CoV-2: Spanish Influenza 1918 and Beyond
The 1918 Spanish Influenza pandemic is very similar to the SARS-CoV-2 pandemic in its geographical spread, contagiousness and demographical impact and a number of public policy measures are suggested based on the 1918 influenza medical and social history.
A mirror in fiction: drawing parallelisms between Camus’s La Peste and COVID-19
La Peste (Albert Camus, 1947), a novel based on a fictional epidemic of plague in the Algerian town of Oran, is relied on for analysing how epidemics force people to change their habits, what type of emotions and behaviours they promote, and which roles are played by different social actors.
Influence of the Peltzman effect on the recurrent COVID-19 waves in Europe
An analysis of the Peltzman effect reveals four main factors contributing to risk compensation, all of which appear to be present in the current COVID-19 pandemic.
A clinical primer for the expected and potential post-COVID-19 syndromes
The range of expected and potential complications from the COVID-19 are reviewed, including direct medical complications, postviral fatiguing symptoms, pandemic stress-related illnesses, and
The histo-blood group antigens of the host cell may determine the binding of different viruses such as SARS-CoV-2
The mechanisms by which some viruses bind to the histo-blood group antigens are reviewed, which could be related to the susceptibility of the individual and are dependent on the Histo- blood group.
Covid-19 Pandemic: A Survival Challenge to Humanity Unseen Thus Far or Déjà Vu Experience?
  • K. Sharov
  • Medicine
    The Beacon: Journal for Studying Ideologies and Mental Dimensions
  • 2020
A hypothesis is proposed that rapid spread of the virus around the world and high percentage of the infected persons, are mainly accounted for by purely social and demographic factors, not by epidemiological nor ecological ones.
Do Severe Complications Like Aneurysms from Kawasaki and Kawasaki-Like Infections Arise in Children with Underlying Articulo-Autonomic Dysplasia/Ehlers-Danlos Syndrome?
A hypothesis is presented that some patients with severe Kawasaki or Kawasaki-like disease from COVID-19 may have underlying Ehlers-Danlos syndrome or related diseases in the arthritisadrenaline


America's Forgotten Pandemic: The Influenza of 1918
Part I. An Abrupt Introduction to Spanish Influenza: 1. The great shadow Part II. Spanish Influenza: The First Wave - Spring and Summer, 1918: 2. The advance of the influenza virus 3. Three
The great influenza : the epic story of the deadliest plague in history
An in-depth account of the deadly influenza epidemic of 1918, a plague that took the lives of millions of people around the world, examines the causes of the pandemic, its devastating impact on early
Living with Enza: The Forgotten Story of Britain and the Great Flu Pandemic of 1918
PART I Influenza: A Primer Prelude: Etaples, Winter 1916-1918 PART II First Wave, March August 1918 Second Wave, September-December 1918 Third Wave, January May 1919 PART III Vietnam, February 2005
Characterization of the 1918 influenza virus polymerase genes
The influenza A viral heterotrimeric polymerase complex (PA, PB1, PB2) is known to be involved in many aspects of viral replication and to interact with host factors, thereby having a role in host
1918 Influenza: the Mother of All Pandemics
New information about the 1918 virus is emerging, for example, sequencing of the entire genome from archival autopsy tissues, but, the viral genome alone is unlikely to provide answers to some critical questions.
A historian's foreword
  • 2003