Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele.

@article{Vidal2005SpanishHL,
  title={Spanish HIV-1-infected long-term nonprogressors of more than 15 years have an increased frequency of the CX3CR1 249I variant allele.},
  author={F. Javier S{\'a}nchez Vidal and Consuelo Vilad{\'e}s and Pere Domingo and Montserrat Broch and Enric Pedrol and David Dalmau and Hernando Knobel and Joaquim Peraire and Cristina Guti{\'e}rrez and Ma Ant{\`o}nia Sambeat and Angels Fontanet and Elisabeth Deig and Mireia Cair{\'o} and Milagros Montero and Crist{\'o}bal Richart and Simon A Mallal},
  journal={Journal of acquired immune deficiency syndromes},
  year={2005},
  volume={40 5},
  pages={527-31}
}
BACKGROUND AND OBJECTIVES The influence of the polymorphisms of the CX3CR1 chemokine receptor gene on the natural history of HIV-1 infection is controversial. This study aimed to determine whether functionally active CX3CR1 genetic variants are associated with long-term nonprogressive infection of >15 years in HIV-1-infected Spanish patients. PATIENTS AND METHODS Two single-nucleotide polymorphisms, V249I (G > A) and T280M (C > T), of the CX3CR1 gene were assessed in 271 Spaniards. These… CONTINUE READING

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