Spaced training induces normal long-term memory in CREB mutant mice

  title={Spaced training induces normal long-term memory in CREB mutant mice},
  author={Jeffrey H. Kogan and Paul W. Frankland and Julie A. Blendy and Jodi Coblentz and Zachary Marowitz and G. Sch{\"u}tz and Alcino J. Silva},
  journal={Current Biology},
BACKGROUND The cAMP responsive element binding protein (CREB) is a transcription factor the activity of which is modulated by increases in the intracellular levels of cAMP and calcium. Results from studies with Aplysia, Drosophila and mice indicate that CREB-activated transcription is required for long-term memory. Furthermore, a recent study found that long-term memory for olfactory conditioning can be induced with a single trial in transgenic Drosophila expressing a CREB activator, whereas in… CONTINUE READING


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