Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.

  title={Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq.},
  author={James T. Wilson and Christina M Ott and Kerstin H{\"o}ner zu Bentrup and Rajee Ramamurthy and Lynnae C. Quick and Steffen Porwollik and P Cheng and Michael McClelland and George Tsaprailis and Timothy Robert Radabaugh and Arthur Hunt and David Tu{\~n}{\'o}n Fern{\'a}ndez and Eike Richter and Mitul Shah and Michelle Kilcoyne and Lokesh Joshi and Mayra A. Nelman-Gonzalez and Steve Hing and Matias Parra and Paula M Dumars and Kristen Norwood and Ramona Bober and Jennifer Devich and Alan J. Ruggles and Carolina Lage Goulart and Mark Rupert and Louis S. Stodieck and Prachi Stafford and Luke Catella and Michael J. Schurr and K. Buchanan and Lisa Morici and James McCracken and Pauline Allen and C Baker-Coleman and Toni-ann Hammond and J{\"o}rg Vogel and Rebecca Nelson and Duane L. Pierson and Heidemarie M. Stefanyshyn-Piper and Cheryl A Nickerson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 41},
A comprehensive analysis of both the molecular genetic and phenotypic responses of any organism to the space flight environment has never been accomplished because of significant technological and logistical hurdles. Moreover, the effects of space flight on microbial pathogenicity and associated infectious disease risks have not been studied. The bacterial pathogen Salmonella typhimurium was grown aboard Space Shuttle mission STS-115 and compared with identical ground control cultures. Global… CONTINUE READING
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1 Excerpt

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